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            地點:廣東 發布時間:2019-03-29 10:53:09
            廣州再生醫學與健康廣東省實驗室(GDL)Thomas Graf實驗室招聘
             
            工作地點:廣州 
             
            實驗室大量招人啦! 
             
            我單位Thomas Graf實驗室將于2019年夏季運行,研究領域是在機理和轉化醫學上的轉錄因子誘導的體細胞轉分化和ips細胞重編程。Thomas Graf是細胞重編程領域的知名學者,曾以第一作者或共同第一作者在Nature, Science, Cell等雜志上發表論文26篇。Thomas Graf也是EMBO和Academia Europea成員,Cell Stem Cell編輯委員會成員,也曾獲許多著名的國際獎項。 
             
            新實驗室將重點研究兩個主要項目: 
             
            a)癌癥項目。通過藥物篩選獲得可激活人白血病細胞內源 C/EBPa的藥物,從而降低其致瘤性。過表達C/EBPa基因誘導人白血病細胞轉分化,移植到免疫缺陷小鼠后抑制腫瘤發生。另一個目標是采用轉分化技術獲得功能性的人膠質細胞,做為危害大腦功能的炎癥疾病模型。這項工作將與中科院廣州生物醫藥與健康研究院藥物篩選平臺負責人Micky Tortorrella、華南理工大學謝華峰、南方醫院和南方醫科大學馮儒以及中科院廣州生物院的Miguel Esteban和王金勇合作完成。 
             
            b)基礎研究。實驗將繼續做細胞轉化機制研究,重點關注染色質,核小體和基因組拓撲的動態研究。我們將結合高通量平臺并開發新的計算工具,以便更好地可視重編程機制的動態發展。長期研究目標是深層次了解細胞命運決定過程,希望發現可能對發育疾病和癌癥有更廣泛影響的新型致病機理。 
             
            我們將與裴端卿,Austin Smith和Hans Schoeler共同合作完成研究。 
             
            廣州實驗室將于2019年夏季運行,成功入選者會立即聘用到巴塞羅那的實驗室培訓,待實驗室運行后回到廣州工作。 
             
            招聘人員: 
             
            博后:(兩名及以上) 
             
            應有博士學位; 
             
            具備生物信息學等領域的研究經驗并取得一定成果; 
             
            精通英語聽說讀寫,有海外留學或工作經驗者優先。 
             
            面試成功者將在巴塞羅那的實驗室接受半年的培訓,然后回到廣州工作。 
             
            助理研究員:(兩名) 
             
            碩士及以上學歷,生物醫學、生物學專業。 
             
            精通英語聽說讀寫。 
             
            個人助理: 
             
            生物醫學或生物學專業,碩士及以上學歷; 
             
            精通英語聽說讀寫; 
             
            個人助理將會擔任Thomas Graf在GDL的實驗室經理一職。 
             
            待遇 
             
            我們提供全球有競爭力的薪酬和優質住宿。 
             
            申請人可發送郵件到thomas.graf@crg.eu,提供簡歷和推薦信并附上推薦人的姓名和電子郵件地址。 
             
            面試安排: 
             
            簡歷接收截止日期:2019年3月15日。 
             
            邀請面試:2019年4月第一周 
             
            面試日期為2019年5月1日 
             
            地點:中科院廣州生物醫藥與健康研究院 
             
            關于TG實驗室的信息可搜索以下網址查詢 
             
             
             
             
            Postdoctoral Positions in the laboratory of Thomas Graf 
             
            Guangzhou Regenerative Medicine and Health Guangdong Laboratory(GDL) 
             
            Guangzhou, China 
             
            We seek to hire two or more postdoctoral fellows to work at our new laboratory, at GIBH, to be opened in the summer of 2019. Our general area of interest is transcription factor-induced transdifferentiation and iPS cell reprogramming of somatic cells, both at the mechanistic and translational levels. Thomas Graf is a pioneer in the cell reprogramming field, being first or senior author of 26 original papers published in Nature, Science or Cell. He is an elected EMBO and Academia Europea member, an editorial board member of Cell Stem Cell, among others, and has won a number of prestigious awards. 
             
            The new lab will focus on two main projects: 
             
            a) Cancer project. Performance of a compound screen to find a drug that activates endogenous C/EBPa in human leukemic cells, thereby impairing tumorigenicity. This is based on our previous work showing that C/EBPa overexpression induces their transdifferentiation and impairs tumorigenesis when transplanted into immunodeficient mice. Another aim is to use transdifferentiation to develop functional human microglia, as a model for inflammatory diseases that affect the brain. This work will be performed in collaboration with Micky Tortorella, head of the screening facility of GIBH; Huafeng Xie, South China University of Technology; Feng Ru, Nanfang Hospital and Southern Medical University; as well as Miguel Esteban and Jinyong Wang at GIBH. b) Basic research. This part of the lab will continue working on mechanisms of cell conversions, focusing on the temporal dynamics of chromatin, nucleosomes and genome topology. 
             
            We will combine high throughput datasets and develop novel computational tools that permit to better visualize dynamic aspects of reprogramming mechanisms. The long-term goal is to obtain a deep understanding of how cells decide their fate, with the hope of discovering new principles that may have wider implications for developmental diseases and cancer. This part of the work will be performed in collaboration with the GIBH labs of Duanqing Pei, Austin Smith and Hans Schoeler. 
             
            Conditions and candidate requirements 
             
            Candidates should have a PhD, experience in related experimental areas and/or in bioinformatics and relevant publications. They should communicate well in spoken and written English. A previous stay abroad would be an asset. Candidates will be trained at our Barcelona lab for half a year before moving to Guangzhou. 
             
            Application conditions and procedure 
             
            The Guangzhou lab will open in the summer of 2019, but candidates will join the Barcelona lab as soon as they are hired. We offer a competitive salary and postdocs are housed in an inexpensive facility on the GIBH campus. Write to Thomas.graf@crg.eu, providing a CV and names and e mail addresses of references. 
             
            Deadline and interview 
             
            The deadline is April 1. Selected candidates will be invited for interviews at the Guangzhou institute in the first week of April; starting date would be May 1, 2019. 
             
            Information about TG’s lab 
             
             
             
             
            推薦給好友(請輸入E-mail): 
                
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